Dopaquel
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References:
- Dopaquel [Professional Information]. Sandton, South Africa: Dr. Reddy’s Laboratories (Pty) Ltd.; 2017.
- Stahl SM. Essential Psychopharmacology. Sixth Edition. Cambridge University Press, 2017;1-626. Tagline information on file.
DOPAQUEL 25. Reg.No.: 43/2.6.5/0429. Each tablet contains quetiapine fumarate equivalent to quetiapine 25 mg. Contains sugar (lactose). DOPAQUEL 100. Reg.No.: 43/2.6.5/0430. Each tablet contains quetiapine fumarate equivalent to quetiapine 100 mg. Contains sugar (lactose). DOPAQUEL 200. Reg.No.: 43/2.6.5/0431. Each tablet contains quetiapine fumarate equivalent to quetiapine 200 mg. Contains sugar (lactose). DOPAQUEL 300. Reg.No.: 43/2.6.5/0432. Each tablet contains quetiapine fumarate equivalent to quetiapine 300 mg. Contains sugar (lactose).For full prescribing information please refer to the professional information approved by the Medicines Regulatory Authority.
Dr. Reddy’s Laboratories (Pty) Ltd., 204 Rivonia Road, Block B, Morningside, Sandton, 2057. Reg.No.: 2002/014163/07.
Tel: +27 11 324 2100. www.drreddys.co.za.
THIS INFORMATION IS INTENDED FOR HEALTHCARE PROFESSIONALS ONLY.
-
References:
- Dopaquel [Professional Information]. Sandton, South Africa: Dr. Reddy’s Laboratories (Pty) Ltd.; 2017.
- Stahl SM. Essential Psychopharmacology. Sixth Edition. Cambridge University Press, 2017;1-626. Tagline information on file.
DOPAQUEL 25. Reg.No.: 43/2.6.5/0429. Each tablet contains quetiapine fumarate equivalent to quetiapine 25 mg. Contains sugar (lactose). DOPAQUEL 100. Reg.No.: 43/2.6.5/0430. Each tablet contains quetiapine fumarate equivalent to quetiapine 100 mg. Contains sugar (lactose). DOPAQUEL 200. Reg.No.: 43/2.6.5/0431. Each tablet contains quetiapine fumarate equivalent to quetiapine 200 mg. Contains sugar (lactose). DOPAQUEL 300. Reg.No.: 43/2.6.5/0432. Each tablet contains quetiapine fumarate equivalent to quetiapine 300 mg. Contains sugar (lactose).For full prescribing information please refer to the professional information approved by the Medicines Regulatory Authority.
Dr. Reddy’s Laboratories (Pty) Ltd., 204 Rivonia Road, Block B, Morningside, Sandton, 2057. Reg.No.: 2002/014163/07.
Tel: +27 11 324 2100. www.drreddys.co.za.
THIS INFORMATION IS INTENDED FOR HEALTHCARE PROFESSIONALS ONLY.
-
References:
- Dopaquel [Professional Information]. Sandton, South Africa: Dr. Reddy’s Laboratories (Pty) Ltd.; 2017.
- Stahl SM. Essential Psychopharmacology. Sixth Edition. Cambridge University Press, 2017;1-626. Tagline information on file.
DOPAQUEL 25. Reg.No.: 43/2.6.5/0429. Each tablet contains quetiapine fumarate equivalent to quetiapine 25 mg. Contains sugar (lactose). DOPAQUEL 100. Reg.No.: 43/2.6.5/0430. Each tablet contains quetiapine fumarate equivalent to quetiapine 100 mg. Contains sugar (lactose). DOPAQUEL 200. Reg.No.: 43/2.6.5/0431. Each tablet contains quetiapine fumarate equivalent to quetiapine 200 mg. Contains sugar (lactose). DOPAQUEL 300. Reg.No.: 43/2.6.5/0432. Each tablet contains quetiapine fumarate equivalent to quetiapine 300 mg. Contains sugar (lactose).For full prescribing information please refer to the professional information approved by the Medicines Regulatory Authority.
Dr. Reddy’s Laboratories (Pty) Ltd., 204 Rivonia Road, Block B, Morningside, Sandton, 2057. Reg.No.: 2002/014163/07.
Tel: +27 11 324 2100. www.drreddys.co.za.
THIS INFORMATION IS INTENDED FOR HEALTHCARE PROFESSIONALS ONLY.
Overview
- Quetiapine is an antagonist at both Serotonin 5HT2A and Dopamine D2 receptors.
About Brand (PI Content)
Pharmacological classification
- A.2.6.5 Central nervous system depressants: Miscellaneous structures.
Mechanism of action
- Quetiapine is an atypical antipsychotic agent which interacts with a broad range of neurotransmitter receptors. Quetiapine exhibits a higher affinity for serotonin (5HT2) receptors in the brain than it does for dopamine D1 and D2 receptors in the brain.
- Quetiapine also has high affinity at histaminergic and adrenergic alpha-1 receptors, with a lower affinity at adrenergic alpha-2 receptors, but no appreciable affinity at cholinergic muscarinic or benzodiazepine receptors.
Strengths
- 25 mg, 100 mg, 200 mg and 300 mg film-coated tablets
Pack size (Blister pack marketed in South Africa)
- Dopaquel 25: 100 film-coated tablets in white HDPE containers.
- Dopaquel 100: 90 film-coated tablets in white HDPE containers.
- Dopaquel 200: 60 film-coated tablets in white HDPE containers.
- Dopaquel 300: 60 film-coated tablets in white HDPE containers.
Indications
- Dopaquel is indicated for the treatment of schizophrenia in individuals 18 years or older
- Dopaquel is indicated for the treatment of manic episodes associated with a bipolar disorder in individuals 18 years or older
Dosage
- For the treatment of schizophrenia: Total daily dose for the first 4 days of therapy is 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3) and 300 mg (Day 4). From Day 4 onwards, the dose should be titrated to the effective dose range of 300 to 450 mg/day. Depending on the clinical response and tolerability of the individual patient, the dose may be adjusted in some patients within the range 150 to 750 mg/day.
- For the treatment of manic episodes associated with bipolar disorder: Total daily dose for the first 4 days of therapy is 100 mg (Day 1), 200 mg (Day 2), 300 mg (Day 3) and 400 mg (Day 4). Further dosage adjustments up to 800 mg/day by Day 6 should be in increments of no greater than 200 mg/day. The dose may be adjusted depending on the clinical response and tolerability of the individual patient, within the range of 200 - 800 mg/day. The usual effective dose is in the range of 400 - 800 mg/day.
*For further information on contra-indications, side-effects, special warning, and storage instructions, please refer to the professional information by clicking below.
