This article addresses essential questions in the management of reflux  esophagitis, offering practical insights into diagnosis, treatment, and patient care. It also highlights key challenges, such as treatment adherence, managing recurrent symptoms, minimizing long-term complications, and tailoring therapies  to individual patient needs, to improve...

Depression and suicide are major public health challenges in South Africa (SA). Although diagnostic tools and treatments are available, access to mental health care—especially in rural areas—remains limited. This review highlights the prevalence, determinants, and treatment of depression and suicide in SA, with emphasis on locally applied diagnostic and...

This review highlights the critical role of structured, long-term management in major depressive disorder (MDD), emphasizing relapse prevention and durable recovery. Using the Kupfer curve as a framework, it examines the phases of treatment, the 5 R’s of depression management, and evidence supporting continuation and maintenance antidepressant therapy...

Essential clinical insights on cardiovascular and diabetes management for healthcare professionals. Features evidence-based research on hypertension control, advanced diuretic therapies, physical activity interventions, and integrated care strategies for improved patient outcomes.

For the e-book find link below: https://cloud.3dissue.com/2650/3471/7897...

This review evaluates the clinical role of duloxetine, a serotonin–norepinephrine reuptake inhibitor (SNRI), in the management of diabetic peripheral neuropathy pain (DPNP). It synthesizes evidence from randomized trials and meta-analysis highlighting its analgesic efficacy, tolerability, and guideline-endorsed positioning as a first-line therapeutic...

This article highlights depression and associated psychiatric comorbidities, such as attention deficit hyperactivity disorder (ADHD), bipolar disorder (BD), and epilepsy, that complicate its diagnosis and clinical course, thereby impacting treatment outcomes. Furthermore, it delves into the importance of implementing personalized care to improve...

This review explores why tolerability matters in antidepressant therapy, the prevalence of key adverse effects, compares the tolerability of antidepressant classes, and discusses the implications of the landmark meta-analysis by Cipriani et al., published in The Lancet, to enable better treatment outcomes in alignment with available clinical evidence.

This review article highlights the unique pharmacological profile and clinical utility of vortioxetine in major depressive disorder (MDD), with emphasis on its efficacy, tolerability, and guideline-endorsed positioning.

This article highlights the clinical profile of bupropion, a NDRI, within the evolving antidepressant landscape. With a distinct mechanism and favorable tolerability, bupropion

Latest evidence-based insights on cardiovascular and diabetes management, featuring breakthrough research on hypertension control, diuretic therapies, and integrated care strategies for improved patient outcomes.

For the e-book find link below: https://cloud.3dissue.com/2650/3471/7897/JSNCardiovascularDiabetes132025/index.html?r=36

This review highlights the multifaceted nature of epilepsy—its diagnosis, clinical presentation, comorbidities, and treatment—with a focus on South Africa's high disease burden and treatment gaps. Furthermore, it underscores the importance of individualized care and early intervention to improve outcomes.

This review highlights the evolving role of serotonin and norepinephrine re-uptake inhibitors (SNRIs) in treating major depressive disorder and related comorbidities. It compares the various SNRIs-duloxetine, venlafaxine, and desvenlafaxine-in terms of efficacy, safety, and tolerability.

This comprehensive review outlines the clinical profile, diagnosis, and management of attention deficit hyperactivity disorder (ADHD) across age groups, with a focus on its neurobiological basis and co-morbidities. It emphasizes the importance of individualized, multimodal treatment strategies, including  stimulants, non-stimulants, and behavioural...

This review highlights the clinical utility and limitation of selective serotonin re-uptake inhibitors (SSRIs) in managing major depressive disorders (MDD), including relapse rates, tolerability issues, and adverse effects. It also explores role of serotonin and norepinephrine reuptake inhibitors (SNRIs) as effective second-line options in SSRI non...

This article uncovers the therapeutic ability of Omeprazole and how it has withstood the test of time in the management of acid-peptic diseases. It highlights various study results elucidating Omeprazole’s efficacy. This article uncovers the therapeutic ability of Omeprazole and how it has withstood the test of time in the management of acid-peptic...

Rational Prescribing of Antidepressants

A focus on the prevalence, pathogenesis, neuropsychological endophenotypes,
neurodevelopmental disorders, the effect of anti-epileptic drugs on ADHD, the
effect of ADHD drugs on seizures and recommendations.

Anhedonia is experienced by ~70% of adults with major depressive disorder
(MDD) and is associated with disturbances of reward circuit pathways, leading
to impaired motivation, pleasure and reward processing.

Post Traumatic Stress Disorder symptoms can have a significant impact on
quality of life and can be highly challenging.

Stress can have severe psychological and physiological consequences.

Lifestyle medicine in mental healthcare: treating the body & mind

Are antidepressants overprescribed?

Psychedelics in mental health: are we there yet?

How can we better identify and manage depression and co-morbid dementia in an ageing population

The article discusses the challenges of treatment adherence in bipolar disorder (BD. Factors affecting adherence include patient, physician, and health system-related issues. Stigma exacerbates non adherence, affecting both patients and families. It explores strategies to improve adherence, where multifaceted interventions are crucial.

This article highlights the pivotal role of PPIs in mitigating the risk of gastroduodenal lesions in patients on prolonged NSAID regimens.

Globally, mental disorders, including bipolar disorder (BD) are among the top 10 leading causes of disease burden

Quetiapine is one of the first-line second-generation antipsychotic drugs recommended for first-episode and multi-episode psychosis.

Quetiapine improves clinical symptoms and neurocognitive impairment in schizophrenia patients who failed to respond to their ongoing antipsychotic treatment

Recent Insights on Sleep Disturbances in Bipolar Disorders

Levocetirizine provides a clinically meaningful improvement in the quality of life (QOL) and overall well-being of individuals.

Oral H1 antihistamines are strongly recommended by guidelines as the first-line treatment of allergic rhinitis and are used quite frequently in clinical treatment.

This study underscores the daily practices in the management of allergic rhinitis (AR) among specialists from several parts of the world. It captures the unbiased opinion of all specialists. A two-part modified Delphi panel was carried out to elucidate global expert management of AR in real life.

Clinical studies highlighting the efficacy of Levocetirizine in the management of seasonal and perennial allergic rhinitis:

Highlighting the clinical efficacy and tolerability of Levocetirizine vs. Cetirizinein the management of seasonal and perennial allergic rhinitis.

The article explains the function and evolution of omeprazole in managing acid-peptic diseases (APDs) including GORD, peptic ulcer disease, and dyspepsia. It illustrates its mechanism, clinical uses, significance in treating various conditions of APDs, and compares its effectiveness with other proton-pump inhibitors.

The comprehensive analysis elucidates the significance of inflammation in asthma, with a primary focus on T helper 2 cells and their pivotal role in type 2 inflammation and subsequent symptoms. Additionally, it explores the potential utilization of leukotriene receptor antagonists to mitigate these pathways

This article delves into the rising prevalence of asthma and allergic rhinitis worldwide, particularly in urban areas, attributed to factors like pollution, climate change, and urbanization. It offers recommendations for optimal patient care, emphasizing medical treatment, inhaler selection, proper technique, vaccination protocols, non-pharmacological...

The article highlights the united airways disease, stressing the interconnection between upper and lower airway diseases, with a focus on asthma and allergic rhinitis. It underscores that patients experiencing both conditions frequently encounter challenges in asthma management, including inadequate control, frequent exacerbations, and increased...

This article distinguishes between bipolar I, bipolar II, and bipolar disorder with mixed features. It explores the significant impact of this disorder and its association with other psychiatric conditions. Additionally, the article underscores the importance of careful diagnosis and examines effective treatment strategies.